dermabond allergic reaction post hysterectomy

Ricci, Joseph A. The surgeon and infectious disease physician agreed that her erythema was an allergic reaction to the Dermabond. Has data issue: false The rash should go away completely within a few weeks. PubMed To date, ACD to topical skin adhesives has been continuously reported in case reports of sporadic events, but systematic studies on their incidence and risk factors have been limited. Is Fixing Pediatric Nail Bed Injuries With Medical Adhesives as Effective as Suturing? As these values did not differ from those of all patients with possible risk factors (p=0.857 and 0.955, respectively), we concluded that previously known risk factors for type IV hypersensitivity did not significantly affect the incidence of ACD in topical skin adhesives. To investigate the clinical characteristics of patients with ACD caused by Dermabond application. Nine patients had positive patch test results to Dermabond; six had developed secondary generalization.The mean time between Dermabond application and ACD onset was 34 days (range, 27-44) in six patients with ACD after the first use, whereas, in the other three patients, it was 5.6 days (range, 4-8) after the second use. Objective: endstream endobj 122 0 obj <>>>/Lang(en-US)/Metadata 119 0 R/Names 123 0 R/Outlines 94 0 R/Pages 118 0 R/Type/Catalog/ViewerPreferences<>>> endobj 123 0 obj <> endobj 124 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Tabs/W/Thumb 113 0 R/TrimBox[0.0 0.0 595.276 841.89]/Type/Page>> endobj 125 0 obj [126 0 R] endobj 126 0 obj <>/Border[0 0 0]/H/N/Rect[445.858 120.461 538.761 109.669]/Subtype/Link/Type/Annot>> endobj 127 0 obj <> endobj 128 0 obj <> endobj 129 0 obj [/ICCBased 153 0 R] endobj 130 0 obj <> endobj 131 0 obj <> endobj 132 0 obj <> endobj 133 0 obj <> endobj 134 0 obj <>stream Don't add any creams to what you were prescribed without checking with your doctor. 0000001536 00000 n The same patient on postoperative day seven. Render date: 2023-05-01T15:29:35.649Z B, Two months after breast augmentation/mastopexy and resolution of her allergic reaction to Dermabond. (2013) Robotically assisted vs laparoscopic hysterectomy among women with benign gynaecologic disease. TREK-1 and TREK-2 knockout mice are not resistant to halothane or isoflurane. Article Google Scholar The number is still staggering even though some estimate that the number of hysterectomies has been steadily declining over the last decade from a peak of 681,234 performed in 2002 to 433,621 cases reported in 2010. Uda, Hirokazu 0000052838 00000 n Wright JD, Ananth CV, Lewin SN, Burke WM, Lu YS, et al. As ACD occurs without risk factors in 23% of patients who used 2-octyl cyanoacrylate or n-butyl cyanoacrylate topical skin adhesives, clinicians and patients should be aware of these facts before using topical skin adhesives. While your rash may resolve quickly, you may need to change bandages or medications your doctor has prescribed. These may include: Post-surgical rashes often go away when your skin is no longer in contact with the irritant. Chi, Daekwan 0000060206 00000 n HysterSisters.com is a patient support website and does not intend to take the place of the relationship between patient and personal physician. 0000015201 00000 n Nicksic, Peter J. Clinical photograph of a patient showing well-demarcated pruritic eczematous eruption, papules, and vesicles that developed in the skin area to which topical skin adhesive was applied. A 63-year-old nulliparous female presented on post-operative day 7 status post total laparoscopic hysterectomy and bilateral salpingo-oophorectomy with sudden onset of erythema and pruritus around all four port site incisions (Figure 1). Care should be taken to apply Dermabond in thin layers to the edges of apposed skin with minimal seepage into the wound cavity. They will examine the rash itself, noting its size, shape, color, severity, and other characteristics. It can have many causes, from Zika virus to allergies. Bowen, C, Bidinger J, Hivnor C, Hoover A, Henning J (2014) Allergic contact dermatitis to 2-Octyl cyanoacrylate. Anonymity, Obligation to The risk factors for ACD were identified using logistic regression analysis of odds ratios. OA Texts journals are led by prominent Ask your HysterSisters. eCollection 2021. Publication types Case Reports MeSH terms Breast Implantation / adverse effects Usatine, R. P. & Riojas, M. Diagnosis and management of contact dermatitis. The material is rapidly converted from a liquid to a solid state via polymerization at room temperature without the need for a catalyst, evaporation of a solvent or application of pressure [5]. Hak Jun Kim. After that, a standard absorbent dressing was applied and changed on the second day after surgery. 10 Replies, Last Reply 12-06-2010, Started By anne17, 10 Replies, Last Reply 03-30-2010, Started By akabezer, 4 Replies, Last Reply 04-02-2007, Started By sdloxham, 10 Replies, Last Reply 04-19-2006, Started By rockin robin, 5 Replies, Last Reply 10-23-2005, Started By ENDH8, 1 Reply, Last Reply 02-13-2005, Started By kelter, 2 Replies, Last Reply 11-23-2004, Started By Northern Angel, 4 Replies, Last Reply 08-08-2004, Started By chudgins, 7 Replies, Last Reply 10-14-2003, Started By audrey1, 4 Replies, Last Reply 03-02-2003, Started By texaggie, 3 Replies, No Uterus - No Ovaries - Yes HRT - Surgical Menopause, 2 Replies, No Uterus - No Ovaries - Yes HRT - Surgical Menopause, 10 Replies, No Uterus - No Ovaries - Yes HRT - Surgical Menopause, 1 Reply, No Uterus - No Ovaries - Yes HRT - Surgical Menopause, 16 Replies, No Uterus - No Ovaries - Yes HRT - Surgical Menopause, 4 Replies, No Uterus - No Ovaries - Yes HRT - Surgical Menopause. 0000002325 00000 n Physician 82, 249255 (2010). Article Objective: To investigate the clinical characteristics of patients with ACD caused by Dermabond application. Current knowledge assembled at an international workshop at BfR, Germany. Accessibility There are two main causes of this type of rash: Contact your doctor immediately if your wound or the area around it becomes red or discolored, hot, or itchy, or if green, yellow, or cloudy discharge drains out. 2009 Jul-Aug;29(4):314-6. doi: 10.1016/j.asj.2009.02.019. 2022. But a cold compress or cooling pack (applied on top of clothing, not directly against the skin) will give your itch a bit of extra relief. Published by John Wiley & Sons Ltd. We retrospectively reviewed 1145 patients (739 patients with 2-octyl cyanoacrylate and 406 patients with n-butyl cyanoacrylate) who underwent skin closure with topical skin adhesives. Its a good idea to let your doctor know if you develop a rash after surgery. Dr. Perry was previously a paid consultant to Ethicon, a Division of Johnson & Johnson and the makers of Dermabond. Epub 2017 Jan 25. 1 These findings were practice-changing for the senior author (N.B. 2021 Jun 15;34(6):736-738. doi: 10.1080/08998280.2021.1935140. 2021 Mar 24;13(3):e14090. Dermabond is a skin adhesive used to close wounds, according to FamilyDoctor.org 2. Interestingly, Nakagawa et al.25 reported a 7.0% incidence of ACD in 100 patients who underwent breast reconstruction surgery. The patient was advised to remove the remaining skin adhesive with petroleum jelly and acetone per the manufacturers instruction and referred to a dermatologist. Her reaction is improved; the sutures were removed without incident on that same day. 8600 Rockville Pike Skin hypersensitivity following application of tissue adhesive (2-octyl cyanoacrylate). Second, the patients in this study were confined to the application of topical skin adhesives to foot and ankle surgeries so that generalization of the results to the whole body can be questioned. Does DERMABOND PRINEO System cause any allergic reactions? The Bactrim DS was continued for one week because of the broken skin and the danger of superinfection. Unable to load your collection due to an error, Unable to load your delegates due to an error. Yagnatovsky M, Pham H, Rokito A, Jazrawi L, Strauss E. Phys Sportsmed. Dermabond is a liquid topical skin adhesive containing a monomeric 2-octyl cyanoacrylate formulation and the colorant D&C Violet #2 which should slough off with desquamation of the epidermis 7-14 days after application. Content may require purchase if you do not have access. Embedded Dermabond may result in a foreign body reaction.8 This report describes contact dermatitis from the use of Dermabond. Bethesda, MD 20894, Web Policies 0000068746 00000 n Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Published online by Cambridge University Press: Studies investigating the inherent risk factors of ACD found that females have a higher susceptibility to ACD than males and due to the difference in hormonal influences and exposure mode to the allergen22. Work as a cosmetician with regular exposure to cyanoacrylate-based eyelash extension glue has also been linked to occupational asthma and allergic rhinitis [27]. This article describes a severe allergic reaction to Dermabond following breast augmentation/mastopexy. Contact dermatitis, patch testing, and allergen avoidance. 0000013256 00000 n 2014; 29 (5): 1-3. 0000004792 00000 n 0000044744 00000 n 43, 625627 (2006). A thin layer of Dermabond remained in place on the epidermis and an erythematous raised wheal with a radius of 1-3cm surrounded each incision (Figure 2). Diffuse Cutaneous Allergic Reaction to Dermabond. Therefore, we thought that although females generally develop ACD more often than males, there is no sex difference in ACD that occurs after using 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives. Thank you for visiting nature.com. It looks like iodine. Dermabond - allergic reaction Need Answers? Sato M, Inomata N, Aihara M. A case of contact dermatitis syndrome caused by Dermabond, followed by contact dermatitis caused by false eyelash glue and Aron alpha glue: possibility of cross-reactions among cyanoacrylates. Generally, very few complications are associated with Dermabond and are usually related to application techniques. These materials can irritate the skin or cause an allergic reaction in some people. Consequently, despite the advantages of topical skin adhesives, many orthopedic surgeons still hesitate to use them due to unpredictable adverse effects. Surgical site infection should always be considered when evaluating a potential allergic reaction to Dermabond or other skin adhesive. 2017 Dec;77(6):414-415. doi: 10.1111/cod.12823. Here's what may be causing them and what you can do to ease your symptoms. If allergic dermatitis is the diagnosis, avoiding the irritant is the first line of defense. and JavaScript. Pamela L. Scheinman, Marc Vocanson, Ari M. Goldminz, Hyo-Eun Kwon, Hye-Jin Ahn, Min Kyung Shin, Stephan Weidinger, Lisa A. Beck, Alan D. Irvine, Young Jae Kim, Dong Jun Lim, Chong Hyun Won, Vasco Silva-Neves, Vitor Hugo, Miguel Pais-Vieira, Mario Mastrocola, Georg Matziolis, Henk Eijer, Julie Bruce, Blessing Oyedemi, Freya Harrison, Young-Je Kim, Mi Ji Choi, Beom Joon Kim, Raiyyan Aftab, Vikash H. Dodhia, Ryckie G. Wade, Scientific Reports Once applied, this film is left to dry and usually lasts five to 10 days on the skin. 2020 John Wiley & Sons A/S . Results: Allergic contact dermatitis: Epidemiology, molecular mechanisms, in vitro methods and regulatory aspects. Reports have also described allergic contact dermatitis following application of cyanoacrylate-containing false eyelash glue [25,26]. 0000056163 00000 n This decline has been attributed to the introduction of minimally invasive techniques such as uterine artery embolization for the treatment of leiomyomata and non-surgical ablative therapies that are now commonly used for abnormal benign uterine bleeding [1]. It took over three weeks to go away. J. Arthroplasty 28, 553556 (2013). Call 911 if you have: Simple home and over-the-counter (OTC) treatments can treat contact dermatitis as well. A, Preoperative view of a 36-year-old woman. A 63-year-old female presented on post-operative day 7 status post total laparoscopic hysterectomy and bilateral salpingo-oophorectomy with sudden onset erythema and pruritus around all four port site incisions. 1)17,19. Poore, Samuel O. The patch test was selectively performed when the lesions exhibited atypical features or a topical skin adhesive was not suspected to be the cause of dermatitis. Unauthorized use of these marks is strictly prohibited. 0000004181 00000 n and I had an allergic reaction to dermabond after surgery (lipoma removal-23 incisions between knee and under breasts). Unable to load your collection due to an error, Unable to load your delegates due to an error. If things get worse, tell your doctor - and also if your symptoms haven't subsided after 3 weeks. Keywords: Singer AJ, Quinn JV, Hollander JE (2008) The cyanoacrylate topical skin adhesives. Background: The Dermabond (2-octyl cyanoacrylate) is a commonly used skin adhesive in plastic surgery. The authors describe the first case series of ACD to Dermabond Prineo where patch testing confirmed the diagnosis in all patients. 0000061721 00000 n The AADA recommends emergency care if you have any of these symptoms. The adhesive property of the compound methyl 2-cyanoacrylate was first described in the literature by H.W. Additional options for both kinds of post-surgical rashes include: Your doctor might decide to prescribe medications to treat your rash. National Library of Medicine Advanced knowledge sharing through global Problems with Dermabond are generally related to application techniques and rarely relate to the chemical nature of the adhesive. 2014. Belsito, D. V. The diagnostic evaluation, treatment, and prevention of allergic contact dermatitis in the new millennium. Surg. startxref Longer-chained cyanoacrylates, such as the 2-octyl cyanoacrylate monomer present in Dermabond, releases less degradation products than the short-chained monomers thus producing less potential histotoxicity. Editor-in-chief, Associations & %%EOF As inappropriate skin closure can lead to cosmetically unacceptable scars, delayed healing, wound dehiscence, or infection, selection of skin closure method is important for orthopedic surgeons1,2,3. Oxford University Press is a department of the University of Oxford. Ophthalmology 110, 291298 (2003). Bitterman A, Sandhu K. Allergic contact dermatitis to 2-octyl cyanoacrylate after surgical repair: humidity as a potential factor. Had gallbladder removed in 2009, all good. Ethicon Inc. (2011) Dermabond Advanced - Topical Skin Adhesive: Instructions for Use, San Lorenzo, Puerto Rico. ACD cases were treated using steroid ointment and oral antihistamines. <<12BBD0C01188574F98AE67673A2EDA8F>]/Prev 461684>> Patch testing can find what's causing your rash. (Log in options will check for institutional or personal access. 2020. Would you like email updates of new search results? scholarly communications through the effective use of editorial and 0000068029 00000 n Contact Dermatitis. and hb``d``;d|gb@ !; M$i``H~ 8Lt:$SuO8u$iHxrNDGQIgIB4YA]HN[RR1(z/o>O:Z)wSQ> J:::2 Ardis AE (1949) US patent nos. Additional components of Dermabond include plasticizers that aid in the flexibility of the wound during the healing process, stabilizers to prolong the shelf life, and polymerization inhibitors to delay the transition of the product from liquid to solid.2 The polymer hydrolyzes in the body, creating formaldehyde, which causes inflammation. Glob. El-Dars LD, Chaudhury W, Hughes TM, Stone NM (2010) Allergic contact dermatitis to Dermabond after orthopaedic joint replacement. 16, 146150 (2006). The next morning, with worsening erythema and itching, she was seen in the emergency room by the surgeon. A 36-year-old white woman on postoperative day four. Skin Wound Care 30, 272286 (2017). 0000010468 00000 n Positive reactions to ethyl cyanoacrylate adhesive (Aron Alpha) occurred in seven of nine patients, to ethyl cyanoacrylate 10% pet. All authors reviewed the manuscript. Provided by the Springer Nature SharedIt content-sharing initiative. aaaai.org/conditions-treatments/allergies/anaphylaxis, nyulangone.org/conditions/eczema-dermatitis/treatments/at-home-therapies-for-eczema-dermatitis, ncbi.nlm.nih.gov/pmc/articles/PMC6170075/, nationaleczema.org/eczema/types-of-eczema/contact-dermatitis/, aaaai.org/Tools-for-the-Public/Allergy,-Asthma-Immunology-Glossary/Contact-Dermatitis-Defined, aaaai.org/tools-for-the-public/conditions-library/allergies/contact-dermatitis-overview, nyulangone.org/conditions/eczema-dermatitis/diagnosis, aad.org/public/diseases/eczema/types/contact-dermatitis/treatment, nyulangone.org/conditions/eczema-dermatitis/treatments/medication-for-eczema-dermatitis, aad.org/public/diseases/eczema/types/contact-dermatitis/patch-testing-rash, aad.org/public/everyday-care/itchy-skin/rash/rash-101, aaaai.org/Tools-for-the-Public/Drug-Guide/Topical-Ointments-Creams, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI. On postoperative day 13, itching began again laterally and her husband injected a single 40-mg dose of Depo-Medrol (Pfizer Inc., New York). Laparosc. Sharma, A. et al. Sunaga, Ataru Singer, A. J., Perry, L. C. & Allen, R. L. Jr. the suspicion of an allergic reaction to Dermabond and recommended application of a thin topical layer of hydrocortisone 1% to affected areas 2-4 times per day. Infect. Anaphylactic allergic reaction, throat closure and systemic pruritus, has been noted following exposure to aspirin and codeine approximately 20 years prior. Dowson, C. C., Gilliam, A. D., Speake, W. J., Lobo, D. N. & Beckingham, I. J. Osmond, M. H., Quinn, J. V., Sutcliffe, T., Jarmuske, M. & Klassen, T. P. A randomized, clinical trial comparing butylcyanoacrylate with octylcyanoacrylate in the management of selected pediatric facial lacerations. 0000012232 00000 n In some cases, your doctor may want to perform a skin biopsy as well. But is jock itch contagious? HysterSisters.com is located at 111 Peter St, Toronto, Canada, M5V2H1 and is part of the VerticalScope network of websites. 8 Days Post Hysterectomy Allergic Reaction to Dermabond - Help! The use of Dermabond as the first choice for closing surgical wounds will only increase with the increasing number of gynaecologic surgeries being performed robotically and laparoscopically. Before Wound closure with 2-octyl cyanoacrylate (Dermabond; Ethicon, Somerville, New Jersey USA) has recently increased in popularity across a wide spectrum of physicians ranging from surgeons to emergency medicine practitioners. Nunley, Julia Nine patients had positive patch test results to Dermabond; six had developed secondary generalization.The mean time between Dermabond application and ACD onset was 34 days (range, 27-44) in six patients with ACD after the first use, whereas, in the other three patients, it was 5.6 days (range, 4-8) after the second use. Responsibilities, Copyright & License Use the Previous and Next buttons to navigate the slides or the slide controller buttons at the end to navigate through each slide. Therefore, we believe that the presence or absence of a patch test would not have significantly affected the results of the study. I had a severe allergic reaction to the antiseptic they put all over your abdomen and thighs prior to surgery( Chlorahexadine glucanate). However, there has never been a reported case resulting from use during gynaecologic surgery until now. Jacoby, Sidney M. Article Webster RG Jr, Slansky HH, Refojo MF, Boruchoff SA, Dohlman CH (1968) The use of adhesive for the closure of corneal perforations. and J.W.C. Hysterectomy Recovery (post hysterectomy), HysterSisters Takes On Partner To Manage Continued Growth And Longevity. 0000105281 00000 n 8 Days Post Hysterectomy Allergic Reaction to Dermabond - Help. Arthur W. Perry, MD, Michael Sosin, Severe Allergic Reaction to Dermabond, Aesthetic Surgery Journal, Volume 29, Issue 4, July 2009, Pages 314316, https://doi.org/10.1016/j.asj.2009.02.019. 0000068378 00000 n Postoperative dressing was performed with povidone-iodine, which was also used for preoperative skin preparation, at intervals of 23days for up to 2weeks after surgery. 0000059447 00000 n Surg. PubMedGoogle Scholar. We report a case of a fulminant allergic reaction to Dermabond following a mastopexy. 7 status post total laparoscopic hysterectomy and bilateral salpingo-oophorectomy with sudden onset of erythema and pruritus around all four port site incisions (Figure 1). 39, 12831289 (2018). Chen, Alex Her wounds were closed with Vicryl sutures (Ethicon), deep dermal polydioxanone sutures (Ethicon), key sutures with Prolene (Ethicon), and Dermabond on the skin. It is a liquid that doctors apply on small wounds and skin surfaces to securely hold the edges together. Wound closure with 2-octyl cyanoacrylate (Dermabond; Ethicon, Somerville, New Jersey USA) has recently increased in popularity across a wide spectrum of physicians ranging from surgeons to emergency medicine practitioners. & Pawlik, T. M. STROBE reporting guidelines for observational studies. Scientific Reports (Sci Rep) Durando, D. et al. J. Patricia McNally, MD, FAAAAI. HysterSisters.com is a massive online community with over 475,000 members and over 5 million posts. Singer, A. J., Kinariwala, M., Lirov, R. & Thode, H. C. Jr. 2017 May;45(2):195-198. doi: 10.1080/00913847.2017.1283208. Key words We deduced that this is due to its lower popularity than 2-octyl cyanoacrylate as a topical skin adhesive. The findings of this study showed that the incidence of ACD was 2.7% in 2-octyl cyanoacrylate and 2.2% in n-butyl cyanoacrylate, but none of the variables were found to increase the risk of ACD. ACD is difficult to predict due to the absence of risk factors, but clinicians and patients should be aware of these facts before using topical skin adhesives. Sarukawa, Shunji Percutan Tech. Plast. 0000017254 00000 n researchers, each embracing the concept that basic knowledge can foster Asahi, Rintaro Yoshimura, Kotaro Kish, J. W., Katz, M. D., Marx, M. V., Harrell, D. S. & Hanks, S. E. N-butyl cyanoacrylate embolization for control of acute arterial hemorrhage. To obtain Similarly, when we analyzed the incidence of ACD in patients without risk factors for type IV hypersensitivity, as suggested in previous studies, the incidence of ACD was 2.5% (15/590) in 2-octyl cyanoacrylate and 2.2% (6/279) in n-butyl cyanoacrylate. There are some reports in the literature regarding Dermabond associated contact dermatitis. The site is secure. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. Dermatitis 25, 99100 (2014). Contraindications to Dermabond use include cyanoacrylate or formaldehyde allergy. Shaw, Daniel W. Although cyanoacrylates traditionally have been associated with low rates of sensitization, allergic contact dermatitis (ACD) to Dermabond products is being increasingly reported after. Wright JD, Herzog TJ, Tsui J, Ananth CV, Lewin SN, et al. In vivo study of wound bursting strength and compliance of topical skin adhesives. Immunol. 69, 763781 (2012). Dumville JC, Coulthard P, Worthington HV, et al. official website and that any information you provide is encrypted A randomized trial comparing octylcyanoacrylate tissue adhesive and sutures in the management of lacerations. This creates a functional glue when placed on the skin. Table 1. (n.d.). Interv. Leggat, P. A., Smith, D. R. & Kedjarune, U. Surgical applications of cyanoacrylate adhesives: A review of toxicity. Sheikh, Mohammad Tafazul A 36-year-old white woman on postoperative day four. The American Academy of Dermatology Association (AADA) says that to determine the type of rash you have and whats causing it, your doctor will consider your health history and perform a physical exam. Pediatr. The chemistry of tissue adhesive materials. Gorski J, Chuang L (2018) Allergic reaction to Dermabond in gynaecologic surgery. and With the escalation in Dermabond usage, which can be attributed to its speed and convenience, more allergic reactions are anticipated. 187, 238248 (2004). Dermabond is a liquid topical skin adhesive containing a monomeric 2-octyl cyanoacrylate formulation and the colorant D&C Violet #2 [3]. 77, 209213 (2007). J. Adhes. Providing cutting-edge scholarly communications Vesicles similar to those seen with poison ivy were visible throughout all incisions, extending only to the area where Dermabond was applied (Figure 1). Slider with three articles shown per slide. hasContentIssue false, Correspondence: Joseph A. Ricci, MD Division of Plastic Surgery Brigham and Women's Hospital 75 Francis Street Boston, Massachusetts 02115 USA E-mail, Copyright World Association for Disaster and Emergency Medicine 2014. Skin inflammation and pruritus abated completely within two days. The purpose of this study was to investigate the incidence and risk factors of ACD after the use of 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives. In fact, n-butyl cyanoacrylate is increasingly preferred for vascular embolization, bleeding hemostasis, or corneal injury repair over skin closure30,31,32. Clipboard, Search History, and several other advanced features are temporarily unavailable. Cochetti, G. et al. : Systematic review. Although there are only a few surgical cases reported regarding allergic reaction to topical application of 2-octyl cyanoacrylate, the current literature is rife with allergic reaction to other cyanoacrylate formulations especially when used during previous surgeries as outlined (Table 1) [13,15-24]. We explain possible remedies and types. Hivnor CM, Hudkins ML (2008) Allergic contact dermatitis after postsurgical repair with 2-octylcyanoacrylate. A prospective, randomized controlled trial comparing n-butyl cyanoacrylate tissue adhesive (LiquiBand) with sutures for skin closure after laparoscopic general surgical procedures. However, despite their long period of usage, their fundamental shortcomings, such as time-consuming nature, cosmetic issues, and the need for removal are still unresolved4,5,6.